"Device for continuous extracorporeal blood purification"

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"Device for continuous extracorporeal blood purification"

Unread postby MrAmsterdam » Wed Nov 30, 2011 2:25 pm

Device for continuous extracorporeal blood purification using target-specific metal nanomagnets

http://ndt.oxfordjournals.org/content/2 ... 8.abstract

Background. The present work illustrates how magnetic separation-based blood purification using ultra-strong iron nanomagnets can be implemented into an extracorporeal blood purification circuit. By this promising technique, today’s blood purification may be extended to specifically filter high-molecular compounds without being limited by filter cut-offs or column surface saturation.

Methods. Blood spiked with digoxin (small molecule drug) and interleukin-1β (inflammatory protein) was circulated ex vivo through a device composed of approved blood transfusion lines. Target-specific nanomagnets were continuously injected and subsequently recovered with the aid of a magnetic separator before recirculating the blood.

Results. Magnetic blood purification was successfully carried out under flow conditions: already in single-pass experiments, removal efficiencies reached values of 75 and 40% for digoxin and interleukin-1β, respectively. Circulating 0.5 L of digoxin-intoxicated blood in a closed loop, digoxin concentration was decreased from initially toxic to therapeutic concentrations within 30 min and purification extents of 90% were achieved after 1.5 h.

Conclusions. Magnetic separation can be successfully implemented into an extracorporeal blood purification device. Simultaneous and specific filtering of high-molecular compounds may offer promising new therapeutic tools for the future treatment of complex diseases, such as sepsis and autoimmune disorders.


Specific molecules react on strong target-specific(?) nanomagnets .
I just wonder if and how that would relate to the natural mechanisms of the human immune system.
Today's scientists have substituted mathematics for experiments, and they wander off through equation after equation, and eventually build a structure which has no relation to reality. -Nikola Tesla -1934
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Re: "Device for continuous extracorporeal blood purification

Unread postby Sparky » Fri Dec 02, 2011 12:14 pm

Would these nano magnets collect in iron rich areas of the body?
Would red blood cells be affected by magnetic fields?
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